What is diuretics Slideshare?
Diuretics: • mainly promotes the excretion of the (Na+), (Cl-) or (HCO3-) and water, • the net result being: – Increase the urine flow, – change urine pH – change the ionic composition of the urine and blood.
What diuretic means?
A type of drug that causes the kidneys to make more urine. Diuretics help the body get rid of extra fluid and salt. They are used to treat high blood pressure, edema (extra fluid in the tissues), and other conditions. There are many different types of diuretics. They are sometimes called water pills.
What are diuretics in medicinal chemistry?
diuretic, any drug that increases the flow of urine. Diuretics promote the removal from the body of excess water, salts, poisons, and accumulated metabolic products, such as urea. They serve to rid the body of excess fluid (edema) that accumulates in the tissues owing to various disease states.
What is the strongest diuretic?
Loop diuretics (furosemide and bumetanide) are the most potent of the diuretics and are widely used in the treatment of pulmonary and systemic edema.
What is diuretics and its types?
The three types of diuretic medications are called thiazide, loop, and potassium-sparing diuretics. All of them make your body excrete more fluids as urine.
Is glucose a diuretic?
Glucose, like mannitol, is a sugar that can behave as an osmotic diuretic. Unlike mannitol, glucose is commonly found in the blood. However, in certain conditions, such as diabetes mellitus, the concentration of glucose in the blood (hyperglycemia) exceeds the maximum reabsorption capacity of the kidney.
What is a common diuretic?
Examples of diuretics include:
- Aldactone (spironolactone)
- Bumex (bumetanide)
- Demadex (torsemide)
- Esidrix (hydrochlorothiazide)
- Lasix (furosemide)
- Zaroxolyn (metolazone)
What is the mechanism of action for diuretics?
They act by diminishing sodium reabsorption at different sites in the nephron, thereby increasing urinary sodium and water losses. A second class of diuretics, sometimes termed aquaretics, instead inhibit water reabsorption by blocking vasopressin receptors along the connecting tubule and collecting duct.
What is the classification of diuretics?
Diuretics Classification of Diuretics Site 1 Proximal Convoluted Tubule (PCT)-Carbonic Anhydrase Inhibitors Site 2 Loop of Henle (LH )- Loop diuretics Site 3 Distal convoluted tubule (DC T)- Thiazide Site 4 Collecting Duct (CD)- Potassium sparing diuretics
How do diuretics affect urine excretion?
Sign up for a Scribd free trial to download now. 2. Diuretics: • mainly promotes the excretion of the (Na+), (Cl-) or (HCO3-) and water, • the net result being: – Increase the urine flow, – change urine pH – change the ionic composition of the urine and blood. 3.
What are potassium sparing diuretics?
20. POTASSIUM-SPARING DIURETICS These are diuretics which do not promote the secretion of potassium into the urine. Potassium is retained and not lost as much as with other diuretics. The term potassium sparing refers to an effects rather than a mechanism or location. Eg: Aldosterone antagonists Spironolactone
How does C-C double bond affect diuretic activity?
Loss of c-c double bond between 3&4 positions of nucleus increases diuretic potency approximately three to ten fold. Direct substitution of the 4,5 or 8 position with an alkyl group usually results in diminished diuretic activity. Substitution of the 6-position with an activating group is essential for diuretic activity .