What is Gene CXCL10?

What is Gene CXCL10?

CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Periapical Periodontitis and Viral Encephalitis. Among its related pathways are ERK Signaling and Cytokine Signaling in Immune system.

Is CXCL10 an isg?

As the CXCL10 promoter contains both putative ISREs and putative STAT-binding sites, it responds to all 3 types of IFN and is considered an ISG (11, 17).

What is the function of CXCL10?

CXCL10 is a small protein that is defined as an ‘inflammatory’ chemokine and binds to CXCR3 to mediate immune responses through the activation and recruitment of leukocytes such as T cells, eosinophils, monocytes and NK cells.

What cells express CXCL10?

Under proinflammatory conditions CXCL10 is secreted from a variety of cells, such as leukocytes, activated neutrophils, eosinophils (12), monocytes, epithelial cells, endothelial cells, stromal cells (fibroblasts) and keratinocytes in response to IFN-γ (13,14).

Is CXCL10 a cytokine?

C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis.

Is CXCL10 a proinflammatory cytokine?

Although CXCL10 was originally identified as a proinflammatory chemokine mediating leukocyte trafficking, it has been found to activate T lymphocytes (Th1) [5], NK cells, macrophages, dendritic and B cells.

Where is CXCL10 produced?

The chemokine CXCL10 was originally identified as an IFN-γ–inducible protein, produced by many cell types in inflamed or infected tissue, such as keratinocytes, macrophages, fibroblasts, and endothelial cells (3). Activated T cells can also produce CXCL10, both in mouse (4) and human (5).

What secretes CXCL10?

Do T cells produce CXCL10?

Activated T cells can also produce CXCL10, both in mouse (4) and human (5). CXCL10 binds to one unique receptor, CXCR3, and acts as chemoattractant for various immune cells (6).

What is the receptor for CXCL10?

CXCL10 specifically activates a receptor, CXCR3, which is a seven trans-membrane-spanning G protein-coupled receptor (6) predominantly expressed on activated T lymphocytes (Th1) (7), natural killer (NK) cells, inflammatory dentritic cells, macrophages and B cells (8,9).