What is Gmall protocol?
The GMALL study group developed these protocols based on concepts employed successfully in the treatment of paediatric mature B-ALL. All used short, alternating cycles of intensive chemotherapy (in an ABABAB pattern) that included high doses of methotrexate and cyclophosphamide.
What is pomp maintenance?
POMP chemotherapy is effective remission induction and maintenance therapy for adults with acute leukemia under the age of 50 and who have not had prior chemotherapy.
What is Calgb regimen?
The CALGB 19802 regimen is characterized by early dose intensification of daunorubicin during induction and post-remission therapy and high-dose cytarabine and methotrexate during post-remission therapy.
What Calgb 8811?
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
What drug is Calgb 10403?
Treatment schema for CALGB 10403. 6-MP, 6-mercaptopurine; 6-TG, 6-thioguanine; Ara-C, cytarabine; CTX, cyclophosphamide; DEX, dexamethasone; DNR, daunorubicin; IT, intrathecally; MTX, methotrexate; PEG, pegylated asparaginase; PO, orally; pred, prednisone; VCR, vincristine.
What is CNS3 leukemia?
Patients were classified into 3 groups (CNS1, CNS2, CNS3) with the following definitions: CNS1=patients with white blood cell (WBC) count in CSF <5 and having no blasts in the CSF, CNS2=patients with WBC count in CSF <5 and having blasts in the CSF, CNS3=patients with WBC count in CSF ≥5 and having blasts in the CSF.
How is hyper-CVAD given?
HyperCVAD Part A usually requires a 4 – 5 day stay in a hospital. Typically, cyclophosphamide, doxorubicin, vincristine, and dexamethasone are all given in the hospital on Days 1 – 4 of each cycle. Vincristine may be given in the clinic on Day 11 and dexamethasone is usually taken at home on Days 11 – 14.
What does Hyper-CVAD stand for?
The term ‘hyper’ refers to the hyperfractionated nature of the chemotherapy, which is given in smaller doses, more frequently, to minimize side effects. ‘CVAD’ is the acronym of the drugs used in course A: cyclophosphamide, vincristine, doxorubicin (also known by its trade name, Adriamycin), and dexamethasone.
What happens when leukemia spreads to the central nervous system?
Central Nervous System Or they may take up residence in the actual brain. However, if that happens, it’s still not brain cancer; it’s considered to be metastatic leukemia. When it spreads to your brain, you may develop symptoms like weakness, facial numbness, headaches and even seizures.
How is CNS leukemia treated?
Most treatment regimens combine multiple doses of intrathecal chemotherapy with high-dose systemic methotrexate and/or cytarabine. Cranial irradiation is less commonly used for prophylaxis but is still the most effective treatment for overt CNS leukemia.