What is granulocyte colony-stimulating factor used for?

What is granulocyte colony-stimulating factor used for?

Granulocyte colony-stimulating factor is used in patients who have certain cancers and neutropenia caused by some types of chemotherapy and in patients who have severe chronic neutropenia that is not caused by cancer treatment. It is also used before an autologous stem cell transplant.

What is G-CSF in immunology?

Granulocyte colony-stimulating factor (G-CSF) is a pleiotropic cytokine playing a major role as regulator of hematopoiesis and innate immune responses. G-CSF represents a powerful and promising cytokine to promote T cell tolerance in pathological conditions associated with a TH1/TH2 imbalance.

What is the most common side effect of G-CSF?

What side effects may I notice from receiving this medicine?

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue.
• back pain.
• dizziness or feeling faint.
• fever.
• pain, redness, or irritation at site where injected.
• pinpoint red spots on the skin.
• shortness of breath or breathing problems.

Does G-CSF increased lymphocytes?

Our data showed that G-CSF treatment induces an increase in peripheral blood lymphocyte counts and a significant reduction in the proliferative response of PBMC to mitogenic stimulation which reverted 14 days after the end of treatment with G-CSF.

Which cells produce G-CSF?

Human G-CSF is produced mainly by monocytes and macrophages (2), but is also produced by fibroblasts (3), endothelial cells (4), and bone marrow stromal cells (5).

What cells release colony-stimulating factor?

Colony-stimulating factors are hematopoietic growth factors that induce clonal growth of hematopoietic progenitors in vitro and in vivo. They are produced by macrophages, stromal cells, endothelial cells, and T lymphocytes in the marrow microenvironment.

What is the functional importance of colony stimulating factors quizlet?

The main function of CSF (Colony Stimulating Factors) is: Increase the immune system by increasing the number of neutrophils produced. _________stimulate expression and differentiation of bone marrow progenitor cells.

What does G-CSF stand for in oncology?

Granulocyte colony stimulating factor (G-CSF) is a class of biological medication that doctors prescribe for people who need to boost their white blood cell count. Doctors refer to low blood cell levels as neutropenia. People usually have low levels of white blood cells as a result of cancer or chemotherapy treatment.

What does G-CSF mean in medical dictionary?

G-CSF: Granulocyte colony-stimulating factor. A colony-stimulating factor that stimulates the production of neutrophils (a type of white blood cell). G-CSF is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents. Also called filgrastim.

What does GCSF stand for?

GCSF stands for Granulocyte Cell Stimulating Factor. Suggest new definition. This definition appears rarely and is found in the following Acronym Finder categories: Science, medicine, engineering, etc.