What is modified Rodnan skin score?
The modified Rodnan skin score (mRSS) is a measure of skin thickness and is used as a primary or secondary outcome measure in clinical trials of systemic sclerosis (scleroderma).
How is modified Rodnan skin score calculated?
The modified Rodnan skin score (MRSS) is a standard outcome measure for skin disease in SSc and calculated by summation of skin thickness in 17 different body sites (total score = 51). Our objective was to evaluate the sensitivity of change over time of individual body sites used in the calculation of total MRSS.
What is skin score?
A semiquantitative measure of cutaneous involvement that improves prediction of prognosis in systemic sclerosis.
What is diffuse systemic sclerosis?
Diffuse cutaneous systemic sclerosis (dcSSc) is a subtype of systemic scleroderma (systemic sclerosis) characterized by skin hardening (fibrosis) and problems in many organs of the body. The disease can occur at any age but mainly affects people between 40 and 50 years of age.
What is Scleroderma derma?
Scleroderma, or systemic sclerosis, is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. The word “scleroderma” comes from the Greek word “sclero,” meaning hard, and the Latin word “derma,” meaning skin.
What is the pinch test for scleroderma?
“In using a skin scoring system, the physician pinches various parts of the patient’s body to test for thickness. The less skin that can be pinched equals a higher score in diagnosing scleroderma,” says Feghali-Bostwick.
How is skin thickness measured?
Skin thickness and stiffness were measured by B-mode ultrasound with SWE imaging on the bilateral fingers and hands. Additional ultrasound evaluation was carried out in 13 patients (9 dcSSc and 4 lcSSc) on their dorsal forearms, followed by skin biopsy conducted in the same skin areas.
Is systemic sclerosis serious?
Systemic sclerosis (SSc, scleroderma) is the most serious form of the disease. This form of scleroderma can occur at any age but is most common in women of childbearing age.
Can you live a long life with diffuse scleroderma?
In general, patients with limited scleroderma have a normal life expectancy. Some have problems with their GI tract, especially heartburn; severe Raynaud’s and musculoskeletal pain; and a small subset can develop pulmonary hypertension that can be life-threatening.