What is NS1 protein in dengue?
Dengue virus (DENV) nonstructural protein 1 (NS1) is a highly conserved 46-kDa protein that contains 2 glycosylation sites (Asn-130 and Asn-207) and 12 conserved cysteine (Cys) residues. Here, we performed site-directed mutagenesis to generate systematic mutants of viral strain TSV01.
Which protein is expressed on surface of dengue infected cell?
Endothelial cell surface expression of protein disulfide isomerase activates β1 and β3 integrins and facilitates dengue virus infection. J Cell Biochem.
Why is the NS1 protein important?
The NS1 protein acts as a scaffolding protein that anchors the replication complex to the endoplasmic reticulum (ER) membrane and interacts physically with NS4B (4).
What is NS1 virus?
The NS1 of influenza A virus is a 26,000 Dalton protein. It prevents polyadenylation of cellular mRNAs to circumvent antiviral responses of the host, e.g., maturation and translation of interferon mRNAs. NS1 might also inhibit splicing of pre-mRNA by binding to a stem-bulge region in U6 small nuclear RNA (snRNA).
What is serotype of dengue?
The Dengue Serotypes Dengue infections are caused by four closely related viruses named DEN-1, DEN-2, DEN-3, and DEN-4. These four viruses are called serotypes because each has different interactions with the antibodies in human blood serum.
Which mosquito causes dengue virus?
Dengue viruses are spread to people through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito.
How do you treat dengue NS1 positive?
No specific treatment for dengue fever exists. While recovering from dengue fever, drink plenty of fluids. Call your doctor right away if you have any of the following signs and symptoms of dehydration: Decreased urination.
What is dengue NS1 IgG IgM?
The dengue antigen NS1, IgG & IgM test measures the dengue virus or antibodies which are produced in response to dengue infection. Dengue fever is a viral infection which is transmitted to humans by mosquitoes which live in tropical and subtropical climates and are responsible for carrying the virus.
What is serotypes in virus?
A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or cells are classified together based on their surface antigens, allowing the epidemiologic classification of organisms to the subspecies level.