What is Pluronic F68 used for?
Gibco® Pluronic® F-68 is a non-ionic surfactant used to control shear forces in suspension cultures. Pluronic® F-68 can also be used to reduce foaming in stirred cultures and reduce cell attachment to glass. Pluronic® F-68 is provided at a concentration of 10% and effective at a working concentration of 0.1%.
What is the role of Pluronic F 68 in cell culture?
Pluronic® F68 (P-F68) is an important component of chemically-defined cell culture medium because it protects cells from hydrodynamic and bubble-induced shear in the bioreactor. Increase in terminal cell density and cell size was seen over time at higher P-F68 concentrations but protein productivity was not impacted.
What is Pluronic acid?
Non-ionic detergent useful for isolation of membrane proteins.
What is Pluronic water?
Pluronic F-127 *10% solution in water* is a nonionic, surfactant polyol (molecular weight approximately 12,500 daltons) that has been found to facilitate the solubilization of water-insoluble dyes and other materials in physiological media.
What is Pluronic 17R4?
Pluronic® 17R4 is a difunctional block copolymer surfactant with terminal secondary hydroxyl groups. A nonionic surfactant that is 100% active and relatively non-toxic. Typical physical properties. Form. Liquid.
What is Kolliphor used for?
Kolliphor EL is a synthetic, nonionic surfactant used to stabilize emulsions of nonpolar materials in water. Kolliphor EL is an excipient or additive in drugs.
What is poloxamer 407 used for?
Poloxamer 407 has been used as a detergent, surfactant, and stabilizer. It facilitates the solubilization of hydrophobic molecules, promoting their rapid and complete dissolution in polar media [6,47].
Is Pluronic FDA approved?
Pluronics (PEOx-PPOy-PEOx) are non-ionic triblock copolymers composed of two hydrophilic side chains of poly (ethylene oxide), PEO, and a central hydrophobic chain of poly (propylene oxide), PPO. They are also known as poloxamers and are non-toxic, biodegradable and FDA approved [22].
What is a Pluronic detergent?
Pluronic® F-127 is a non-ionic detergent useful for isolation of membrane proteins. It has been found to facilitate the solubilization of water-insoluble dyes and other materials in physiological media.
What is polyethoxylated castor oil?
Polyoxyl castor oil (polyethoxylated castor oil, Kolliphor EL, or Cremophor EL) is prepared by reacting ethylene oxide with castor oil in a ratio of 35:1. This results in a compound in which the hydroxyl groups of the castor oil triglyceride are ethoxylated, forming polyethylene glycol ethers [1].
What are the side effects of poloxamer 407?
They are costly, and are known to cause side effects including ectopic bone formation, formation of seroma,9) neuropathy by neuritis, osteolysis, and soft tissue swelling. Moreover, the risk of retrograde ejaculation,11) male infertility and malignancy were also recently reported.