What is saccharated iron oxide?
Description. Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis.
Is venofer a blood product?
Venofer (iron sucrose) Injection is an iron replacement product used to treat iron deficiency anemia in people with kidney disease. Venofer is usually given with another medication to promote the growth of red blood cells (such as Aranesp, Epogen, or Procrit).
How does iron sucrose injection work?
Iron sucrose injection is in a class of medications called iron replacement products. It works by replenishing iron stores so that the body can make more red blood cells.
What is the most common side effect of iron sucrose?
Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Pain, swelling, or redness at the injection site may occur. If these effects continue or worsen, tell your doctor.
Who manufactures Venofer?
Luitpold Pharmaceuticals, Inc., headquartered in Shirley, NY, manufactures and distributes over 65 pharmaceutical products including Venofer(R)(iron sucrose injection, USP), the leading IV iron therapy in the U.S., through its human health subsidiary, American Regent, Inc.
What drug class is Venofer?
Coordination complexIron sucrose / Classification
Why is sucrose used in injections?
Pfanstiehl brand, high-purity low endotoxin (HPLE) Sucrose is used in the biopharmaceutical industry to stabilise proteins, lipids, and carbohydrates throughout the formulation and freeze / thaw lifecycle of therapeutics.
Which injection used for increase hemoglobin?
Epoetin injection is a man-made version of human erythropoietin (EPO). EPO is produced naturally in the body, mostly by the kidneys. It stimulates the bone marrow to produce red blood cells. If the body does not produce enough EPO, severe anemia can occur.
Is iron sucrose safe?
IV iron sucrose has been reported to be safe with an excellent profile in clinical use; it can be administered without a test dose. The incidence of serious life-threatening anaphylaxis with iron sucrose is 0.002% versus 0.6-2.3% and 0.04% with high-molecular-weight iron dextran and ferric gluconate, respectively.
Is iron bad for kidneys?
While iron therapy is a common treatment for such patients, new evidence suggests that iron is potentially toxic and its long-term consequences are unknown. Given that intravenous iron can damage normal kidneys, its potential toxicity might be even greater in kidneys affected by disease.
What is ferric saccharate used for?
Ferric saccharate. A glucaric acid-iron conjugate that is used in the treatment of IRON-DEFICIENCY ANEMIA, including in patients with chronic kidney disease, when oral iron therapy is ineffective or impractical.
How do you make sucroferric oxyhydroxide?
Sucroferric oxyhydroxide is prepared by basifying a ferric chloride solution, giving a polynuclear iron (III)-oxyhydroxide suspension which is mixed with potato and maize starches and sucrose.
What is the mechanism of action of iron saccharate?
6.7 Mechanism of Action. Following intravenous administration, iron saccharate is dissociated into iron and sucrose and the iron is transported as a complex with transferrin to target cells including erythroid precursor cells. The iron is then incorporated into hemoglobin as the cells mature into red blood cells.
What is iron sucrose used for?
Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis.