What is shikimic acid pathway PPT?

What is shikimic acid pathway PPT?

The shikimate pathway is a seven step metabolic route used by bacteria, fungi, algae, parasites, and plants for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan). …

What is shikimic acid pathway in pharmacognosy?

The shikimate pathway (shikimic acid pathway) is a seven-step metabolic pathway used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (tryptophan, phenylalanine, and tyrosine). This pathway is not found in animal cells.

What is produced by the shikimic acid pathway?

The shikimic acid pathway is responsible for the production of vitamins and aromatic amino acids such as phenylalanine, tyrosine, and tryptophan. It is also a source of precursors which are converted to an array of natural products.

Why the name shikimic acid pathway is given?

The shikimate biosynthesis pathway provides precursors for aromatic molecules in bacteria, fungi, apicomplexan, and plants, but not in animals [2, 7]. Shikimic acid is named after the highly toxic Japanese shikimi ( Illicium anisatum ) flower from which it was first isolated [8].

Which is a precursor of shikimic acid pathway?

Phenylalanine and tyrosine are the precursors used in the phenylpropanoids biosynthesis. The phenylpropanoids are then used to produce the flavonoids, coumarins, tannins and lignin. The first enzyme involved is phenylalanine ammonia-lyase (PAL) that converts L-phenylalanine to trans-cinnamic acid and ammonia.

How many hydroxyl groups are present in shikimic acid?

Shikimic acid is a cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer).

Where does the shikimic acid pathway occur?

shikimic acid pathway The key metabolic pathway in the biosynthesis of the aromatic amino acids – tyrosine, phenylalanine, and tryptophan – which occurs in plants, bacteria, and fungi, but not in animals.

Where does shikimate pathway occur?

The shikimate pathway is found only in microorganisms and plants, never in animals. All enzymes of this pathway have been obtained in pure form from prokaryotic and eukaryotic sources and their respective DNAs have been characterized from several organisms.

What do you mean by shikimic acid?

Medical Definition of shikimic acid : a crystalline acid C7H10O5 that is formed as a precursor in the biosynthesis of aromatic amino acids and of lignin.

What is shikimic acid found in?

Shikimic acid can also be extracted from the seeds of the sweetgum (Liquidambar styraciflua) fruit, which is abundant in North America, in yields of around 1.5%. For example, 4 kg of sweetgum seeds is needed for fourteen packages of Tamiflu. By comparison, star anise has been reported to yield 3% to 7% shikimic acid.

What functional groups are in shikimic acid?

Shikimic acid is a cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and microorganisms.

What contains shikimic acid?

Much of the current supply of shikimic acid is sourced from the seeds of Chinese star anise (Illicium verum). Supply from star anise seeds has experienced difficulties and is susceptible to vagaries of weather. Star anise tree takes around six-years from planting to bear fruit, but remains productive for long.

What is the shikimic acid pathway?

Shikimic Acid Pathway Shikimic Acid Illiciumanisatum L. Illicinaceae {Shikimino-ki in Japanese} (1885) E. coli mutant strains pathway intermediate Shikimic Acid Pathway • Important for aromatic compounds • Precursor of aromatic amino acids (Phe, Tyr, Try) biosynthesis in bacteria, fungi & higher plants.

What does shikimic acid stand for?

Shikimic Acid Illicium anisatum L. Illicinaceae {Shikimino-ki in Japanese} (1885) E. coli mutant strains pathway intermediate. Shikimic Acid Pathway. Important for aromatic compounds

What is the correct order of the shikimate pathway?

The shikimate pathway consists of seven steps, starting with the condensation of phosphoenolpyruvate and erythrose-4-phosphate (Figure 6.2). Their condensation and cyclization lead to the formation of shikimic acid and end with the synthesis of chorismic acid (Figure 6.2).

What is the role of shikimic acid in phenolic synthesis?

5. Role of Shikimic Acid Pathway: • Starting Point in The Biosynthesis of Some Phenolics Phenyl alanine and tyrosine are the precursors used in the biosynthesis of phenylpropanoids. The phenylpropanoids are then used to produce the flavonoids, coumarins, tannins and lignin.

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