What is the best treatment for porokeratosis?

What is the best treatment for porokeratosis?

Topical imiquimod cream has been shown to be effective for treating classic porokeratosis of Mibelli (PM). Ingenol mebutate has shown efficacy in the treatment of PM.

Is porokeratosis a rare disease?

Porokeratosis is a rare skin disorder affecting fewer than 200,000 Americans. It typically presents as small, round patches on your skin that have a thin, raised border. Although the condition is usually benign, a small number of people may develop skin cancer within a lesion.

Is porokeratosis and autoimmune disease?

Porokeratosis is considered to result from the inability to eliminate an abnormal keratinocyte clone induced by genetic factors and various stimuli, including sunlight, artificial ultraviolet light, viral infections, immunosuppressive conditions (hematologic malignancies, organ transplants, or autoimmune disease), and …

What is porokeratosis?

Porokeratosis is a clonal disorder of keratinization characterized by one or more atrophic patches surrounded by a clinically and histologically distinctive hyperkeratotic ridgelike border called the cornoid lamella.

Does porokeratosis ever go away?

There is no known cure for porokeratosis and treatment is generally disappointing. However, the appearance may improve with the following measures: 5-fluorouracil cream. Calcipotriol cream.

What does linear porokeratosis look like?

What is linear porokeratosis? Porokeratosis is a group of skin conditions in which there is abnormal keratinisation. The skin lesions that result are reddish patches (which can be dry or atrophic) with a well-defined ridge-like border called a cornoid lamella [1].

Is porokeratosis curable?

Why do you get porokeratosis?

The cause of this condition is unknown, though exposure to sunlight or other forms of radiation, genetic factors and a weakened immune system have been suggested as possible risk factors . Porokeratosis of Mibelli may sometimes harm normal tissue underlying the affected area; it may also develop into skin cancer .

Is porokeratosis life threatening?

Very rarely, porokeratosis-associated squamous cell carcinomas may metastasize and cause death.