What is the characteristic histopathological hallmark for pemphigus vulgaris?
Histology of pemphigus vulgaris Early lesions of pemphigus vulgaris show suprabasal epidermal acantholysis, clefting and blister formation. The blister cavity may contain inflammatory cells including eosinophils and rounded acantholytic cells with intensely eosinophilic cytoplasm and a perinuclear halo.
Can the Pfizer vaccine cause bullous pemphigoid?
Urticarial bullous pemphigoid after Pfizer dose #1 in a patient with a chronic idiopathic pericarditis on anakinra. A 72-year-old male physician developed a diffuse maculopapular dermatitis four days after Pfizer COVID-19 vaccine.
What is Asboe Hansen?
The Asboe-Hansen sign (also known as “indirect Nikolsky sign'” or “Nikolsky II sign”) refers to the extension of a blister to adjacent unblistered skin when pressure is put on the top of the bulla. This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989).
What does Acantholysis mean?
Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders.
Can vaccines trigger bullous pemphigoid?
Background: Influenza vaccination has been suggested to be a trigger for bullous pemphigoid (BP). In our area most new patients with BP are admitted to hospital.
Can pemphigus vulgaris be cured?
There’s currently no cure for pemphigus vulgaris (PV), but treatment can help keep the symptoms under control. The main aim of treatment is to heal the blisters and prevent new ones forming. Steroid medication (corticosteroids) plus another immunosuppressant medication are usually recommended.
What is worse pemphigus or pemphigoid?
Pemphigus is a chronic and potentially fatal disease and patients should be counseled accordingly. Bullous pemphigoid is usually less severe and can resolve in 1 – 2 years.
What is bullous pemphigoid and how is it treated?
Bullous pemphigoid. Treatment usually includes medications, such as prednisone, and other drugs that suppress the immune system. Bullous pemphigoid can be life-threatening, especially for older people who are already in poor health.
What is the pathophysiology of pemphigus vulgaris?
Pemphigus encompasses a group of auto-immune blistering diseases of the skin and mucous membranes. Included in this group is pemphigus vulgaris, a bullous disease involving the skin and mucous membranes, which may be fatal if not treated with appropriate immunosuppressive agents.
What is bullbullous pemphigoid (BP230)?
Bullous pemphigoid is the result of an attack on the basement membrane of the epidermis by IgG +/- IgE immunoglobulins ( antibodies) and activated T lymphocytes (white blood cells). The target is the protein BP180 (also called Type XVII collagen ), or less frequently BP230 (a plakin).
What is the mortality and morbidity associated with bullous pemphigoid (BP)?
Corresponding author: A Aslam [email protected] Bullous pemphigoid and pemphigus vulgaris are diseases of an ageing population Both are associated with high morbidity and mortality, with the commonest cause of death being opportunistic infections from prolonged immunosuppression