What is the classification of antimalarial drug?
Currently available antimalarials fall into three broad categories according to their chemical structure and mode of action (Appendix 9-A): 1. Aryl aminoalcohol compounds: quinine, quinidine, chloroquine, amodiaquine, mefloquine, halofantrine, lumefantrine, piperaquine, tafenoquine. 2.
What do you mean by antimalarial agents?
Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women.
What are the various antimalarial drugs and their mechanism of action?
Mechanism of Action: In Plasmodium falciparum quinine has been found to inhibit nucleic acid synthesis, protein synthesis, and glycolysis; it also binds with hemazoin in parasitized erythrocytes. Quinine is effective as a malarial suppressant and in control of overt clinical attacks.
Which drug is used as antimalarial in pharmacognosy?
In fact, the first successful antimalarial drug was quinine, an alkaloid, which was extracted from Cinchona tree. In the present review work, the alkaloids isolated and reported recently (2013 till 2019) to possess antimalarial activity are presented.
How does antimalarial medication work?
How malaria tablets work? Malaria is caused by a parasite which is transmitted via mosquito bites. Some malaria tablets work by stopping the parasite from multiplying in red blood cells meaning your immune system can fight the infection before you develop symptoms.
What are antimalarial drugs used for?
Antimalarial drugs are used for the treatment and prevention of malaria infection. Most antimalarial drugs target the erythrocytic stage of malaria infection, which is the phase of infection that causes symptomatic illness (figure 1).
What is antimalarial write its example?
Antimalarial: A drug directed against malaria. The original antimalarial agent was quinine which took its name from the Peruvian Indian word “kina” meaning “bark of the tree.” A large and complex molecule, quinine is the most important alkaloid found in cinchona bark.
What are the contraindications of antimalarial drugs?
Contraindications. Amodiaquine should not be administered to patients with known hypersensitivity and should be avoided in patients with a history of hepatotoxicity, hepatic impairment, neutropenia or retinopathy.
How is malaria treated and prevented?
There’s currently no vaccine available that offers protection against malaria, so it’s very important to take antimalarial medication to reduce your chances of getting the disease. However, antimalarials only reduce your risk of infection by about 90%, so taking steps to avoid bites is also important.
What are the main causes of malaria?
Malaria is caused by the Plasmodium parasite. The parasite can be spread to humans through the bites of infected mosquitoes.
What are the names of antimalarial drugs?
What is the causative agent of malaria?