What is the most current recommendation for the treatment of Helicobacter pylori?
The best options appear to be fluoroquinolone-containing sequential therapy (a PPI and amoxicillin for five to seven days followed by a PPI, a fluoroquinolone, and nitroimidazole for five to seven days) or LOAD therapy (levofloxacin, omeprazole [Prilosec], nitazoxanide [Alinia], and doxycycline for seven to 10 days).
What is the second line treatment for H. pylori?
The Maastricht V/Florence Consensus Report recommends bismuth quadruple therapy, or fluoroquinolone-amoxicillin triple/quadruple therapy as the second-line therapy for H. pylori infection.
What drugs are used in triple therapy?
Background: Triple therapy (proton pump inhibitor, clarithromycin and amoxicillin or an imidazole) is the first-line treatment for Helicobacter pylori infection. However, the effectiveness of triple therapy is decreasing due to the increase in antibiotic resistance.
What is sequential therapy for H. pylori?
The sequential therapy is a simple dual therapy including a proton pump inhibitor (PPI) plus amoxicillin 1 g (both twice daily) given for the first 5 days followed by a triple therapy including a PPI, clarithromycin 500 mg, and tinidazole (all twice daily) for the remaining 5 days [Zullo et al. 2007].
What is the first line therapy for peptic ulcer disease with a positive H. pylori?
First line therapy for H. pylori eradication includes a proton pump inhibitor (PPI), clarithromycin and amoxicillin or metronidazole (for penicillin-allergic patients) for seven to 14 days. PPIs work synergistically with antibiotics to eradicate H. pylori.
Which drug is used as second line salvage therapy for persistent H pylori infection?
Another alternative, the use of a quadruple regimen (i.e. PPI, bismuth, tetra-cycline and metronidazole), has been generally used as the optimal second-line therapy after PPI-clarithromycin-amoxicillin failure, and has been the recommended ‘rescue’ regimen in several guidelines [Malfertheiner et al.
Does triple therapy for H. pylori work?
PPI based triple therapy is significantly more effective for H pylori eradication than dual therapy consisting of two antibiotics or a PPI plus an antibiotic. 2 ,28 PPI given twice daily is significantly more effective than once daily in combination with clarithromycin and amoxicillin or nitroimidazole.
Can ciprofloxacin treat H. pylori?
Ciprofloxacin when combined with omeprazole and bismuth is efficacious for eradication of H pylori.
What is the significance of triple therapy treatment?
Uses for Triple Therapy This medicine is used to treat patients with H. pylori infection and duodenal ulcers caused by H. pylori bacteria.
Why is triple therapy used?
What are the treatment options for Helicobacter pylori (HP) infection?
For the last two decades, the recommended treatment for H. pylori eradication is the standard triple therapy (Papastergiou et al. 2014a, b), using a proton pump inhibitor or ranitidine bismuth citrate, combined with clarithromycin and amoxicillin or metronidazole.
What is the success rate of triple therapy for Helicobacter pylori?
PPI-based triple therapy has been described to be losing its efficacy for H. pylori, with eradication cure rates as low as 50% to 70%, due to high rates of antibiotic resistance, high rates of antibiotic-associated side effects and low compliance[5].
Does Helicobacter pylori infection cause insulin resistance?
H. pyloriinfection may be correlated with insulin resistance, increased total and low density lipoprotein cholesterol and decrease of high density lipoprotein in infected peoples[3]. Also, H. pylorihas a critical role in the other extragastric diseases such as chronic urticaria[4].
Is levofloxacin effective for Helicobacter pyloria?
Levofloxacin containing triple treatment are recommended as rescue treatment for infection of H. pyloriafter defeat of first-line therapy. The rapid acquisition of antibiotic resistance reduces the effectiveness of any regimens involving these remedies.