Which enzyme is responsible for photoreactivation of DNA?
What type of mutation does Photolyase repair?
Photolyase, a class of flavoproteins, uses blue light to repair two types of ultraviolet-induced DNA damage, cyclobutane pyrimidine dimer (CPD) and pyrimidine-pyrimidone (6–4) photoproduct (6–4PP).
What is dark repair?
2. Excision repair (dark repair): a) A light-independent repair mechanism that involves three steps: (i) recognition of, binding to, and removal of damaged DNA. (ii) repair synthesis of excised region by DNA polymerase.
How does direct repair of DNA work?
Direct repair is defined as the elimination of DNA and RNA damage using chemical reversion that does not require a nucleotide template, breakage of the phosphodiester backbone or DNA synthesis.
What causes pyrimidine dimers?
Pyrimidine dimers are molecular lesions formed from thymine or cytosine bases in DNA via photochemical reactions. Ultraviolet light (UV) induces the formation of covalent linkages between consecutive bases along the nucleotide chain in the vicinity of their carbon–carbon double bonds.