How often does Lamictal cause Steven Johnson Syndrome?

How often does Lamictal cause Steven Johnson Syndrome?

In other cases, the rash could signal a serious medical condition. Two severe complications, Stevens-Johnson syndrome and toxic epidermal necrolysis, occur in only 0.04 percent of people or 1 in every 2,500 taking lamotrigine.

Which drug is most likely to cause Stevens-Johnson syndrome?

The medicines that most commonly cause Stevens-Johnson syndrome are:

• allopurinol.
• carbamazepine.
• lamotrigine.
• nevirapine.
• the “oxicam” class of anti-inflammatory drugs (including meloxicam and piroxicam)
• phenobarbital.
• phenytoin.
• sulfamethocazole and other sulfa antibiotics.

Can you have a mild case of Stevens-Johnson syndrome?

Skin and mucous membrane involvement initially can be mild or it can rapidly progress. Some individuals may have severe skin symptoms and mild mucosal involvement while others have mild skin involvement and severe mucosal symptoms.

Does Lamictal cause weight gain?

If you’re concerned that taking the medication Lamictal (lamotrigine) may cause you to gain weight, there’s good news. It probably won’t affect your weight much at all. If anything, you’re more likely to lose weight because of Lamictal than to gain weight, but either way, the changes will probably be pretty small.

How quickly does Stevens-Johnson syndrome start?

If your case of SJS is caused by a drug, symptoms appear about one to three weeks after you start taking medication. The flu-like illness (fever, cough and headache, skin pain) is followed first by a rash and then peeling. In the case of TEN, some people even lose hair and nails.

Should I stop taking Lamictal if I get a rash?

Unless you’re sure the rash isn’t related to it, you should stop taking Lamictal immediately and contact your doctor. There’s no way to tell if a mild rash will turn into something more serious. Depending on your reaction, your doctor may lower your dose of or take you off of the medication entirely.

How quickly does Steven Johnson Syndrome progress?

Clinical Presentation. The typical clinical course of SJS begins within 8 weeks (usually 4 to 30 days) following the first exposure to the causative agent. Only in very rare cases where an inadvertent rechallenge occurs do symptoms appear within hours.

Does Lamictal speed up metabolism?

Lamotrigine metabolism also exhibits the phenomenon of “autoinduction” (increase in its own metabolism during the course of therapy) [104], similar to the first-generation AED carbamazepine, with an approximately 20% reduction in steady-state serum/plasma concentrations if dosage is not escalated.

Has anyone lost weight on lamotrigine?

In the first clinical trials involving the drug, 5% of adults with epilepsy lost weight while taking Lamictal, while between 1% and 5% of patients with bipolar I disorder gained weight while on the drug. 3 The researchers didn’t disclose how much weight the patients gained or lost.

How does a Lamictal rash start?

The Lamictal rash is caused by a hypersensitivity reaction to the drug Lamictal. A hypersensitivity reaction happens when your immune system overreacts to a compound or drug. These reactions can show up shortly after taking a drug or several hours or days later.

Is Steven Johnson Syndrome autoimmune?

Stevens-Johnson syndrome is a hypersensitivity reaction. This means the immune system overreacts, causing inflammation, skin rashes and other symptoms, but it’s not contagious.

Can lamotrigine cause stevenstevens-Johnsons syndrome?

Stevens-Johnsons Syndrome (SJS) is an immune-complex-mediated hypersensitivity reaction and has been linked as an adverse side effects to many drugs. Lamotrigine, an anticonvulsive medication and also a commonly used mood stabiliser, can be associated with this adverse reaction.

What is the prevalence of stevenstevens–Johnson syndrome (SJS)?

Stevens–Johnson Syndrome (SJS), a dermatological emergency is a rare condition; with a reported incidence of around 2.6 to 6.1 cases per million people per year with a mortality rate of around 5%.

What is the relationship between phenobarbital and Stevens-Johnson syndrome?

Severe adverse cutaneous reactions, including Stevens–Johnson syndrome and toxic epidermal necrolysis, have long been associated with the use of aromatic anticonvulsant drugs (phenobarbital, phenytoin, and carbamazepine).

How common are adverse reactions to lamotrigine in the US?

Of a total of 4,364 papers regarding lamotrigine, 122 studies met our inclusion and exclusion criteria. In total, 18,698 patients were included with 1,570 (8.3%) of patients experiencing an adverse dermatologic reaction. The incidence of Stevens-Johnson syndrome/toxic epidermal necrolysis was 0.04%.