What kind of drug is Integrilin?

What kind of drug is Integrilin?

Integrilin (eptifibatide) injection is a platelet aggregation inhibitor indicated for treatment of acute coronary syndrome (ACS) managed medically or with percutaneous coronary intervention (PCI), and treatment of patients undergoing PCI (including intracoronary stenting).

Where are glycoprotein found in human cells?

Glycoprotein Examples and Functions Glycoproteins are found on the surface of the lipid bilayer of cell membranes. Their hydrophilic nature allows them to function in the aqueous environment, where they act in cell-cell recognition and binding of other molecules.

Is clopidogrel an ADP?

Adenosine diphosphate receptor antagonists Thienopyridine adenosine 5′-diphosphate (ADP) antagonists approved for antiplatelet activity in the United States include clopidogrel, ticlopidine, prasugrel, and ticagrelor.

Is clopidogrel an agonist?

Clopidogrel. The P2Y12 antagonist that is currently most widely used as an antithrombotic agent is clopidogrel. It is recommended in current clinical guidelines for prevention of further thrombotic events following acute coronary syndrome and ischaemic stroke [23].

Are parenteral GP IIb/IIIa inhibitors available for clinical use?

The lack of benefit, including increased mortality, in patients with ACS or undergoing PCI showed by the oral GP IIb/IIIa inhibitors stopped their investigations, and therefore only parenteral forms are available for clinical use. There are three parenteral GP IIb/IIIa antagonists approved for clinical use: abciximab, eptifibatide, and tirofiban.

What are the generalities of glycoprotein IIb/IIIa inhibitors?

Glycoprotein IIb/IIIa inhibitors—generalities. The glycoprotein (GP) IIb/IIIa receptor is an integrin that mediates the final common pathway of platelet aggregation. In particular, the GP IIb/IIIa receptor is a heterodimer consisting of the alpha IIb and beta3-subunits.

What are the different types of GP IIb/IIIa antagonists?

There are three parenteral GP IIb/IIIa antagonists approved for clinical use: abciximab, eptifibatide, and tirofiban. Eptifibatide and tirofiban, also known as “small molecule agents,” do not induce immune response and have lower affinity for the GP IIb/IIIa receptor than abciximab.

What does GPIIb/IIIa stand for?

Glycoprotein IIb/IIIa inhibitors. In medicine, glycoprotein IIb/IIIa inhibitors, also GpIIb/IIIa inhibitors, is a class of antiplatelet agents.